The 5 Most Explosive Moments From Mel Gibson's Latest Joe Rogan Interview (#2254)
The long-awaited return of Hollywood icon Mel Gibson to *The Joe Rogan Experience* (JRE), specifically episode #2254, has once again proven to be one of the most talked-about and controversial podcast events of the year. As of this December 2025 update, the interview stands out not just for its deep-dive into Gibson’s upcoming projects but for the unvarnished, unfiltered discussions on highly sensitive and politically charged topics.
The conversation, which spanned several hours, delivered everything fans expect from a high-profile JRE guest: a mix of health speculation, religious debate, and pointed political commentary. Gibson, the award-winning actor and director, used the platform to promote his new film while simultaneously igniting a firestorm of discussion across the internet, solidifying the episode as a must-listen for anyone tracking current cultural flashpoints.
Mel Gibson: A Brief Biographical Profile and Filmography
Mel Columcille Gerard Gibson is an American-born Australian actor, director, producer, and screenwriter, known globally for his intense performances and controversial public persona. Born on January 3, 1956, in Peekskill, New York, he moved with his family to Sydney, Australia, at the age of 12, where he later studied acting at the National Institute of Dramatic Art (NIDA).
- Birth Name: Mel Columcille Gerard Gibson
- Born: January 3, 1956 (Peekskill, New York, U.S.)
- Nationality: American and Australian
- Breakout Roles: Max Rockatansky in the Mad Max series (1979–1985) and Martin Riggs in the Lethal Weapon series (1987–1998).
- Directorial Triumphs: Gibson won the Academy Awards for Best Director and Best Picture for the historical epic Braveheart (1995). He also directed the highly controversial and successful film The Passion of the Christ (2004) and the critically acclaimed Hacksaw Ridge (2016).
- Recent Project: His appearance on JRE #2254 was primarily to discuss his upcoming directorial effort, the thriller Flight Risk, starring Mark Wahlberg.
The Unconventional Health and Cancer Cure Claims
One of the most immediate and explosive takeaways from the JRE #2254 interview involved Gibson's discussion on unconventional medical treatments, particularly regarding cancer. This segment, featuring both Gibson and Dr. Riordan, quickly went viral and drew immediate scrutiny from the medical community.
Ivermectin, Fenbendazole, and Stage Four Cancer
Gibson shared personal anecdotes about friends who, he claimed, had successfully overcome "Stage Four cancer" by utilizing a combination of antiparasitic drugs like Ivermectin and Fenbendazole.
Rogan and Gibson spent a significant amount of time discussing how these drugs, which have shown some anticancer effects in laboratory settings, were allegedly used by his contacts to achieve remission.
The conversation was particularly timely, as the topic of Ivermectin had already been a major cultural flashpoint due to its use during the global pandemic. Gibson's claims, while unsubstantiated by mainstream medical bodies for cancer treatment, were powerful enough to enter the political sphere.
This JRE segment reportedly influenced First Lady of Florida, Casey DeSantis, to advocate for $60 million in state funding for cancer research, specifically citing the need to test unconventional drugs like Ivermectin, which Gibson had championed on the podcast. This connection between a podcast conversation and significant state-level policy highlights the immense cultural reach of Rogan's platform.
Stem Cell Therapy and Personal Experience
Beyond the controversial cancer discussion, Gibson and Dr. Riordan also detailed the life-changing results Gibson and his father experienced with stem cell therapy at the Stem Cell Institute in Panama.
Gibson spoke about the regenerative potential of stem cells and how the treatment had positively impacted his family's health and quality of life, offering a more mainstream, albeit still cutting-edge, perspective on medical innovation. This segment provided a contrast to the more speculative Ivermectin claims, grounding the health discussion in a recognized, though costly, form of therapy.
Deep Dive into Religion and Political Commentary
Gibson, a devout Traditionalist Catholic, never shies away from deep religious and political discussions, and his JRE appearance was no exception. The conversation quickly moved from Hollywood to theology and state politics, revealing some of his most deeply held beliefs.
The Gospels as 'Verifiable History' and Sedevacantism
The director of The Passion of the Christ and the upcoming sequel, The Resurrection of the Christ: Part One (slated for 2027), made an impassioned case for his faith, asserting that the Gospels are "verifiable history."
The religious discussion took a sharper turn when Gibson touched upon the topic of Sedevacantism, a position held by some Traditionalist Catholics who believe the papal chair has been vacant since the Second Vatican Council.
His arguments, which suggest a schismatic view of the modern Catholic Church, drew immediate rebuttals and commentary from Catholic commentators, who dissected his claims on various platforms, confirming the controversial nature of his religious beliefs and his willingness to discuss them openly on a massive platform like JRE.
Criticism of California's Leadership and Wildfires
The interview also featured a sharp segment on state politics, with both Rogan and Gibson condemning the leadership of California, particularly Governor Gavin Newsom, over the state's handling of devastating wildfires.
Gibson offered a personal connection to the issue, detailing how his own home was threatened by the fires during the time of the interview. The discussion centered on perceived mismanagement of tax revenue, forest maintenance, and emergency response, painting a picture of frustration shared by many California residents. This segment provided a rare glimpse into Gibson's views on local governance and environmental policy, adding another layer of controversy to the episode.
The sheer breadth of topics—from promoting Flight Risk to discussing stem cells, Ivermectin, Sedevacantism, and political failures—makes JRE #2254 one of the most comprehensive and polarizing interviews in the podcast's recent history, ensuring Mel Gibson remains a figure at the center of cultural debate.
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